Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease
Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD).A previous study showed Activin ALKALINE PITCHER WHITE A, whose transcription is upregulated by calcium influx via synaptic NMDARs, suppresses eNMDAR signaling.Th